BASIC STUDIES IN CLOTTING MECHANISMS AS PERTAIN TO TRAUMA AND MASSIVE TRANSFUSION THERAPY
Annual progress rept., 1 Dec 1962-30 June 1963
NEW YORK UNIV NY SCHOOL OF MEDICINE
Pagination or Media Count:
A study of factors effecting platelet function and the possible formation of AHG from a precursor is discussed. Methods for studying platelet function were established. These include assay of factor 3, as previously described by the investigator, platelet agglutination, release of nucleotides by thrombin, agglutination by ADP and release of C14 seroto nin. As a model for studying platelet damage, the effect of immune complexes, employing varying ratios of antigen and antibody will be used. The possibility that AHG may be formed from a precursor is suggested by recent studies on von Willebrands disease. A sensitive, reproducible method for measuring AHG was developed, using a modification of the partial thrombo plastin time with kaolin.