Accession Number:

AD0408202

Title:

CALCIPHYLAXIS IN WOUND HEALING

Descriptive Note:

Annual rept. 1 Sep 1962-31 Aug 1963

Corporate Author:

MONTREAL UNIV (QUEBEC)

Personal Author(s):

Report Date:

1963-08-31

Pagination or Media Count:

15.0

Abstract:

In the exploration of different calciphylactic syndromes, it was shown that a variety of agents such as distilled water, mechanical trauma, formaldehyde, croton oil, or histamine liberators selectivity inhibit skin calcification at the point where they are applied within the challenged area. We also found that in rats, topical direct calcinosis, normally induced in the subcutaneous connective tissue at the site of KMnO4-injection, is prevented if the animals are maintained on a diet virtually deficient in both calcium and phosphate. A calciphylatic syndrome characterized by heavy calcium deposits in the snout, paws and esophagus induced by certain agents was investigated. Moreover, a technique was developed for the study of mast cells. Selective necrosis was calcification at the corticomedullary junction of the kidney in the rat was produced in experiments with hexadimethrine bromide, an agent in clinical use for the inactivation of heparin.

Subject Categories:

  • Weapons Effects (Biological)

Distribution Statement:

APPROVED FOR PUBLIC RELEASE