Accession Number:

AD0404937

Title:

EXPERIMENTAL STUDY AND CLINICAL USE OF LYSOZYME,

Descriptive Note:

Corporate Author:

JOINT PUBLICATIONS RESEARCH SERVICE WASHINGTON D C

Personal Author(s):

Report Date:

1963-04-04

Pagination or Media Count:

19.0

Abstract:

A study was made of the antibacterial, antiviral, and antitumor effect of lysozyme prepared by the method of direct crystallization from egg albumin. Experiments on chick embryos and mice in models of staphylococcal- and coli-sepsis showeyme had both a prophylactic and therapeutic effect on the two infections. In monkey kidney tissue cultures 250-500 gamma of lysozyme prevented the cytopathogenic action of the influenza virus and of adenoviruses. In human cancer cell cultures HeLa and HEp2500 2000 gammaml of lysozyme suppressed development of the monolayer of cells when introduced into the medium before the start of cultivation its effect on the formed layer was less pronounced. Lysozyme inhibited dehydrogenase activity and respiration of human tumor cells. The rate of growth suppression of Ehrlichs tumor cells in animal experiments was up to 45. Lysozyme has been successfully used to cleanse carriers of staphylococoi that were resistant to other antibiotics. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE