RESEARCH ON THE PRODUCTION AND IMMUNOLOGICAL EXAMINATION OF ARTIFICIAL ANTIGENS CONTAINING KNOWN SUGARS (OR OLIGO-SACCHARIDES) AS THE DETERMINANT GROUPS, IN RELATION TO THE IMMUNO CHEMICAL ANALYSIS OF ENTEROBACTERIAL O-ANTIGENS (ENDOTOXINS)
Final technical rept., 1 Dec 1961-30 Nov 1962
WANDER (A) FORSCHUNGSINSTITUT GMBH FREIBURG (GERMANY F R)
Pagination or Media Count:
Enterobacterial O-antigens are complex toxic lipopolysaccharides on the surface of the bacterial cell wall. Their specificity is given by oligosaccharidic side chains of the highly branched polysaccharide components. By serologic inhibition techniques the determinant endgroups of various O- antigen factors were identified. Three and six tenths-dideoxy-hexoses frequently play a role as endgroups of important deter minants in O-antigens of highly pathogenic strains, such as Salmonellc paratyphi, Salmonella typhi, Escherichia coli 111, and many others. The artificial antigens were nontoxic, in con trast to the bacterial O-antigens, which are part of the so-called endotoxic complex.