RESISTANCE OF GUINEA PIGS IMMUNIZED WITH BOTULINUM TOXOIDS TO AEROGENIC CHALLENGE WITH TOXIN
ARMY BIOLOGICAL LABS FREDERICK MD
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Data are presented showing that active immunization of guinea pigs with botulinum toxoids afforded a high level of protection to challenge with botulinum toxins by the respiratory route. Resistance to challenge by this route was similar to resistance afforded to challenge by the parenteral and oral routes. The high survival percentages obtained in these studies made it impossible to establish any relationship between serum antitoxin titer and resistance to challenge. This report presents results of some studies to determine resistance afforded actively immunized guinea pigs to challenge with botulinum toxins by the respiratory route. Expression of LD50 estimates in guinea pig intraperitoneal LD50 suggests that normal guinea pigs show essentially similar susceptially to the five toxins administered by the respiratory route. The respiratory susceptibility is more closely related to their oral susceptibility than to their intraperitoneal susceptibility with at least four of the five types.