Accession Number:

AD0404855

Title:

SYNERGISTIC ACTIVITY BETWEEN PR8 INFLUENZA VIRUS AND STAPHYLOCOCCUS AUREUS IN THE GUINEA PIG

Descriptive Note:

Technical manuscript

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Report Date:

1963-04-01

Pagination or Media Count:

22.0

Abstract:

The synergistic interaction of influenza virus Type A, PR8 strain and Staphylococcus aureus in guinea pigs was studied by aerosol exposures to mixtures of the organisms. The reaction of the host was a toxic death occurring within 48 hours. Quantitative studies of this phenomenon have shown that the concentration of virus ad ministered was critical. On the other hand, in activated or partially inactivated staphylococci, in combination with the virus, were capable of inducing high mortality in guinea pigs. No significant differences were observed between the multiplication of either organism and the corresponding single-agent controls. Evidence suggesting a possible mechanism of toxic action is discussed.

Subject Categories:

  • Anatomy and Physiology
  • Animal Husbandry and Veterinary Medicine
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE