DIFFERENTIAL RADIOSENSITIVITY OF FIRST- AND SECOND-SET RESPONSES TO ALLOGENEIC AND XENOGENEIC SKIN GRAFTS IN SUBLETHALLY IRRADIATED MICE
NORTHWESTERN UNIV EVANSTON IL TECHNOLOGICAL INST
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Data are presented demonstrating the differential radio sensitivity of the first and second-set responses of sublethally irradiated 670 rad mice previously sensitized with allogeneic H-2 difference, xenogeneic rat or both allogeneic and xenogeneic skin grafts. The second-set response is more radioresistant than is the first-set response. The second-set response to a xenogeneic graft remains intact during and following recovery fro-he effects of sublethal irradiation. While intact for a brief period following irradiation, the second-set response to an allogeneic skin graft was abrogated by sublethal irradiation 670 rad. Concurrent pre sensitization with allogeneic and xenogeneic skin grafts prevented the abrogation of the second set response to the allogeneic graft by sublethal irradiation. The first-set response to an allogeneic graft recovered from the effects of sublethal irradiation prior to the recovery of the first-set response to a xenogeneic graft.