Accession Number:

AD0404157

Title:

THE BONE-BODY FLUID CONTINUUM,

Descriptive Note:

Corporate Author:

CALIFORNIA UNIV LOS ANGELES

Personal Author(s):

Report Date:

1962-01-01

Pagination or Media Count:

49.0

Abstract:

The high concentrations and products of calcium and phosphate ions in the blood and extracellular fluid of boneless lower vertebrates are associ ated with low body temperatures, high ionic strengths of the solution, low serum alkaline phosphatase activity, and other variable factors that decrease the chemical activity and se the solubility of calcium phosphate salts. In all researches dealing with lower vertebrates, it is absolutely essential to take into considera tion the influences of thermodynamic solubility products, organic phosphate inhibitor of crystal nucleation, complexes of calcium with organic acids, calcium and phosphate binding capacity of protein, and rate of exchange of various ions with apatite. Bone evolved from a specific alteration in the DNA hereditary program of the germ cell. The biochemical mechanisms associated with the interaction of environmental and genetic factors that promote osteogenesis should be uncovered by further interdisciplinary re searches in comparative biology. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE