Accession Number:

AD0402971

Title:

STUDIES ON THE MECHANISM OF CELL DAMAGE IN LIVER AND KIDNEY CELLS AND IN HEART MUSCLE FIBERS AS REVEALED BY ELECTRON MICROSCOPY

Descriptive Note:

Final rept. 15 Nov 1961-14 Nov 1962

Corporate Author:

JIKEI UNIV TOKYO (JAPAN) SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

1962-11-14

Pagination or Media Count:

34.0

Abstract:

Thioacetamide and yellow phosphorus were respec tively administered into the stomach of Wister rats and periodical changes 15 min. - 48 days occurring in liver cells were observed with light and electron microscopes. In the initial stage of acute thioacetamide poisoning, liver cell in jury appeared in the central zone and then spreads to the periphery. Electron microscopy revealed a transitional figures from REr to SEr, b single limiting membrane of mitochondria and increased electron density, c decreased glycogen content, d enlargement of nucleoli, and e decrease or complete disappearance of Palades granules, etc. These findings appeared from about 30 minutes and become prominent with the lapse of time. In the initial stage of acute yellow phosphorus poisoning, liver injury appear ed in the peripheral zone. Electron microscopi cally the main changes consisted of a transitional figures between REr to SEr, b swelling of mitochondria, c decrease of glycogen, d appeaof lipid droplets, e enlargement of nucleoli, f decrease and disappearance of Palades granules, etc. These figures were first encountered at 15 minutes, and they became prominent with the lapse of time.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE