DIFFERENTIAL RESPONSE TO ALLOGENIC AND XENOGENIC SKIN GRAFTS BY SUBLETHALLY IRRADIATED (670 RAD) AND NON-IRRADIATED MICE SENSITIZED BY VARIOUS MEANS
NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CA
Pagination or Media Count:
Twelve to 14 week old female LAF1 mice were pre-sensitized either with 3 i.p. injections of BALBc or rat spleen or skin cells, by means of two consecutive BALBc or rat skin tail grafts. One week following the last injection or the rejection of the second, skin graft, the mice either were grafted with LAF1, BALBc, C3D2 and rat skin or they received 670 red whole body X radiation and were grafted immediately thereafter. The data indicate that skin grafts induce a are vigorous and are radioresistant second-set response than do dissociated cells. Pro-sensitization with allogenic spleen cells resulted in prolonged survival of subsequent allogenic skin grafts in sublethally irradiated mice. The second-set response to a xenogenic skin graft was found to be more radioresistant than was that to an allogenic graft. The converse was true with regard to the first-set response.