Accession Number:

AD0343262

Title:

PHYSICAL PERFORMANCE FOLLOWING INHALATION OF GB

Descriptive Note:

Porton technical paper

Corporate Author:

CHEMICAL DEFENCE EXPERIMENTAL ESTABLISHMENT PORTON DOWN (UNITED KINGDOM)

Personal Author(s):

Report Date:

1963-05-01

Pagination or Media Count:

22.0

Abstract:

Maximal work tests have been carried out on 20 subjects, and submaximal work tests on a further 20 subjects, using an electrically braked bicycle ergometer. Following the inhalation of GB nominal dose 5 ugkg there was a small decrease in maximal rate of working relative to control days following the inhalation of isopropanol, there was a small increase in the rate of working relative to control days. Sub-maximal work tests showed an increase of oxygen consumption following inhalation of isopropanol. The test series showed no increase of ventilation following inhalation of GB, implying that the increase in O2 consumption was achieved by an increased efficiency of gas transfer in the lungs no change of pulse rate, rise of body temperature, respiratory rate, tidal volume, respiratory quotient, or ventilatory equivalent for oxygen was observed following administration of GB. The group inhaling isopropanol showed a significant increase of extraventilation in the 15 min following exercise on the test day this response was not shown by those inhaling GB. Local symptoms of GB inhalation were unnoticed during vigorous exercise.

Subject Categories:

  • Personnel Management and Labor Relations
  • Biochemistry
  • Anatomy and Physiology
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE