Accession Number:

AD0342332

Title:

EA 1476 and EA 2233

Descriptive Note:

[Technical Report, Summary Report]

Corporate Author:

CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD

Personal Author(s):

Report Date:

1963-08-01

Pagination or Media Count:

77

Abstract:

The actions of EA 1476 and EA 2233 are generally similar to many psychotropic compounds of military interest i.e., they yield varying degrees of incapacitation, both physical and mental. Both compounds, however, are unique in eliciting an unequivocal orthostatic hypotension at dose levels far below those required to pro duce mild mental incapacitation. No human studies have yet been made on isomers 2 and 4. Primate data do indicate, however, that these specific stereoisomers possess a degree of pharmacologic potency, at least equivalent to that of the racemic mixtures studied in human subjects. Secondly, no human or animal data are available on the effects of the aerosolized agents. It is believed that data should yet be obtained from the following studies 1 Exposure of animal and human subjects to the aerosolized racemate. 2 Exposure of human subject to oral doses of stereoisomers 2 and 4.

Descriptors:

• cardiovascular physiological phenomena
• cardiovascular system
• cardiac arrhythmias
• veins
• blood
• body weight
• heart rate
• animal structures
• cells
• dermatologic agents
• pharmacology
• materials
• movement disorders
• spectra
• analgesia
• biomedical research
• bone marrow

Subject Categories:

• Chemical, Biological and Radiological Warfare

Distribution Statement:

[A, Approved For Public Release]