Accession Number:

AD0322280

Title:

Screening Studies with Variola Virus

Descriptive Note:

Technical rept.

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1958-10-01

Pagination or Media Count:

106.0

Abstract:

An investigation was initiated to screen variola virus. The experimental data are concerned with methods of assaying the virus quantitatively, determining optimal conditions for culture growth, and the effect of various physical and chemical reagents on its viability. Viability after lyophilization and the storage stabilities of both liquid and dried organisms were noted. Monkeys, as a test host, were infected by the parenteral, oral, intranasal, and aerosol routes. The disease picture in these animals was similar to that of human infections. The findings of viral cytopathogenicity and propagation of the organisms in different tissue cultures are given.

Subject Categories:

  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE