Accession Number:

AD0296480

Title:

HETEROGENEITY OF CANCER CELL POPULATION WITH REGARD TO THE NATURAL DRUG RESISTANCE OF CANCER CELL

Descriptive Note:

Corporate Author:

SASAKI FOUNDATION MEDICAL INSTITUTION TOKYO (JAPAN)

Personal Author(s):

Report Date:

1963-12-31

Pagination or Media Count:

30.0

Abstract:

The actual state of drug resistance of tumor cell population is a matter of grading when it is considered on the cellular level. Every tumor has its own peculiar grade of natural drug resistance and the grade is not a fixed value but it can fluctuate naturally around a certain level within a limited range of variations corresponding to the resistance of its cell population. Population analysis of a neoplastic population, after establishing single cell clones from the population, has so far demonstrated that the tumor cell population is not of a homogeneous constitution but is a heterogeneous complex of cells of fluctuated grades of drug resistance. The resistance of a tumor cell population, therefore, is the averaged sum of all that of its constituents which differ from each other in their grade of resistance.

Subject Categories:

  • Anatomy and Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE