Accession Number:

AD0296478

Title:

EXPLORATION OF NEW CHEMOTHERAPEUTICS FOR INFECTIOUS DISEASES

Descriptive Note:

Corporate Author:

KITASATO INST TOKYO (JAPAN)

Personal Author(s):

Report Date:

1962-10-31

Pagination or Media Count:

35.0

Abstract:

Protomycin is a new antibiotic belonging to cycloheximide group with activities against Endameba hystolytica and saccharomyces, particularly resembling to streptimidone by Frohardt et. al. in Parke Davis Company. Degradation products of protomycin were compared with corresponding ones simultaneously obtained from streptimidone. A structure for protomycin was proposed on the basis of the products in referring to the established structure of streptimidones. Purification of cephalomycin was carried out with isoelectric precipitation and chromatography on Sephadex and DEAE cellulose. The unitary activity increased twice. The amino acid constitution glycine, serine, glutamic and aspartic acids, threonine, proline, alanine, methionine, leucine, valine, phenylalanine, histidine, cystine, tyrosine and lysine and N- terminal amino acid aspartic or glutamic acid were determined.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE