INVESTIGATIONS ON THE PROBLEM OF FORMATION AND PATHOPHSIOLOGICAL SIGNIFICANCE OF BIOGENIC AMINES IN SUBLETHAL RADIATION INJURIES
COLOGNE UNIV (GERMANY F R)
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As a result of 2736 determinations of 7 biogenic amines in urine and blood of rats by means of fluorescence spectrofotometry it has been found, that a single short time total body irradiation of 400, 600 and 800 r leads, according to the dose, to a partly considerable increase of tryptamine, 5- hydroxytryptamine, bufotenine, histamine, 3-hydroxytyramine, noradrenaline and adrenaline. The overexcretion of these amines, which was followed up for 21 and 8 days respectively was to be demonstrated from the first day after irradiation. Further 736 fluorescence spectrofotometric determinations of amines, carried out in hourly intervals after total body irradiation of the experimental animals showed, that for 5-hydroxytryptamine, histamine, noradrenaline and adrenaline an overexcreti fourth hour after radiation treatment is to be demonstrated. By means of further 6928 fluorescence spectrofotometric amine determinations we could show that the measured overexcretion of the above named 7 amines is to be reduced vastly or prevented completely by application of certain inhibitors phenylacetic acid, alpha-methyldopa in opposition to other substance tried for radiation protection the named inhibitors have been applied post radiationem.