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STRESS STUDIES IN RATS FED GLYCINE CONTAINING DIETS
ARCTIC AEROMEDICAL LAB FORT WAINWRIGHT ALASKA
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When rats are fed a semisynthetic diet containing 10 glycine and then stressed cold water swim, the animals maintain liver glycogen at a much higher level than do animals treated similarly but fed the diet without the added glycine. During a 3-hour recovery following the stress, the glycine-fed animals synthesize considerable liver glycogen while the control-fed rats show no net deposition of liver glycogen. Muscle creatine levels were determined before stress, after stress and following recovery from stress in animals prefed creatine-control diet and creatine-glycine diet. The activity of the enzymes phosphorylase and glycogen synthetase was determined at the three times in the stress procedure in muscle from animals prefed four diets the control, the glycine, the creatinecontrol and the creatine-glycine rations. Active phosphorylase activity was found to be increased in animals on all of the diets as a result of stress and remained elevated at the end of the recovery period. Glycogen synthetase activity of muscle was lowered at all times in the procedure as a result of feeding diets supplemented with glycine, creatine, or both. The variations in muscle enzyme activity did not conform to the observed changes in liver glycogen and thus do little to help explain the mechanism of the glycine effect. Author
APPROVED FOR PUBLIC RELEASE