Accession Number:

AD0294815

Title:

EFFECT OF LOW AMBIENT TEMPERATURES ON SPECIFIC AND NONSPECIFIC RESISTANCE OF MICE TO BACTERIAL DISEASE

Descriptive Note:

Corporate Author:

UTAH UNIV SALT LAKE CITY

Personal Author(s):

• MARCUS,S.
• MIYA,F.

Report Date:

1962-08-01

Pagination or Media Count:

1.0

Abstract:

Experiments were designed to compare specific and nonspecific resistance to induced bacterial disease in mice placed at 2 C. The animals were acclimatized or unacclimatized to the low temperature. It was found that specific resistanceAFFORDED THE MAXIMAL PROTECTION POSSIBLE WHEREAS NONSPECIFIC RESISTANCE WAS OF RELATIVELY LOW EXTENT. The low ambient temperature did not interfere with protection gained from specific immunization provided the cold-exposed mice were caged in small groups 10 per group as compared to individually caged animals. The difference in results between isolated and grouped animals was not due to conservation of heat by huddling. It appears that the effect of isolation contributes to enhanced mortality following challenge. Author

Descriptors:

• *COMMUNICABLE DISEASES
• *EXPOSURE(PHYSIOLOGY)
• ESCHERICHIA
• IMMUNITY
• KLEBSIELLA
• MICE
• ELECTRICAL RESISTANCE
• STAPHYLOCOCCUS
• STRESS(PSYCHOLOGY)

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE