Accession Number:

AD0294541

Title:

RESPIRATION AND PHOSPHORYLATION IN LIVER MITOCHONDRIA AND HOMOGENATES FROM ADRENALEC-TOMIZED RATS

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s):

• STRICKLAND, E. HARDIN

Report Date:

1962-10-06

Pagination or Media Count:

22.0

Abstract:

The effect of adrenalectomy on respiration and phosphorylation in liver mitochondria and homogenates was studied. The efficiency of oxidative phosphorylation was unaltered in mitochondria and homogenates from adrenalectomized rats. Nevertheless, the maximal phosph rylative capacity per cell appeared to decrease followingADRENALECTOMY. This decre se se ed to result from a general reduction in the protein per cell in a renalectomized rats, rather than from a specific effect on respiratory enzymes. The lowered cellular protein seemed to be caus d by a lowered caloric intake in adrenalectomized rats. The results of this inv stigation suggest that physiological levels of corticosteroids do not directly affect respiration or phosphorylation in the liver. Author

Descriptors:

• *PROTEINS
• *LIVER
• *ADRENAL GLANDS
• *CORTICOSTEROID AGENTS
• *PHOSPHORYLATION
• METABOLISM
• CELLS(BIOLOGY)
• EXCISION
• RESPIRATION
• SURFACES

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE