THE TOLERANCE OF GUINEA PIGS TO AIR BLAST WHEN MOUNTED IN SHALLOW, DEEP, AND DEEP-WITH-OFFSET CHAMBERS ON A SHOCK TUBE
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LOVELACE FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH ALBUQUERQUE NM
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ONE HUNDRED AND EIGHTEEN GUINEA PIGS WERE EXPOSED TO AIR BLAST IN SHALLOW, DEEP, AND DEEPWITH-OFFSET CHAMBERS MOUNTED ON A SHOCK TUBE. The LD50- 24 hours, in terms of the incident shock pressures measured adjacent to the chambers, was calculated by probit analysis to be 34.9 psi, 19.5 psi, and 26.8 psi for animals in the shallow, deep, and deep-with-offset chambers, respectively. According to the LD50 incident pressures, the shallow chambers offered the most protection against air blast the deep chambers, the least. Comparing the LD50pressure dose at the animals location revealed little difference in their tolerance to overpressure, per se i.e., LD50 reflected pressures measured by gauges within the deep and deep-with-offset chambers were 34.6 psi and 35.9 psi, respectively. The LD50 incident shock pressure of 34.9 psi in the shallow chambers was considered to be the dose at the animals location in that instance. The protection against blast provided by the three chambers and the response of animals to the particular pressure time patterns encountered are discussed.
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