Mixed Infections of Venezuelan Equine Encephalomyelitis and Q Fever in Macaca Mulatta Monkeys
ARMY BIOLOGICAL LABS FREDERICK MD
Pagination or Media Count:
Studies suggest that the Macaca mulatto monkey, when exposed simultaneously to aerosols of the Trinidad strain of Venezuelan equine encephalomyelitis virus 500 to 700 respiratory infectious doses and the AD strain of Coxiella burnetii 10 to 30 respiratory infectious doses, exhibits a concurrent mixed infection with VEE and Q fever. The course of the dual infection in the monkey is characterized by an abrupt early onset of viremia and febrile response 48 to 72 hours to VEE that lasts approximately eight days. The onset of Q fever, as characterized by a rickettsemia, occurs in the final stages of VEE infection seventh to eleventh days recovery of rickettsiae from monkey blood persists beyond the fifteenth day after aerosol exposure. The presence of VEE virus-neutralizing antibody and Q fever complement-fixing antibody in 28-day convalescent serum supports these findings.
- Medicine and Medical Research