Accession Number:

AD0293174

Title:

CONTINUING STUDIES ON THE METABOLISM OF FATTY ACIDS AND RELATED SUBSTANCES IN ANIMALS EXPOSED TO COLD

Descriptive Note:

Corporate Author:

TUFTS UNIV BOSTON MASS SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

1956-12-01

Pagination or Media Count:

1.0

Abstract:

Liver slices from rats exposed to 0 to 2 C. environmental temperature from 24 to 48 hours showed in a Krebs - HCO3 medium, a greatly depressed capacity to synthesize fatty acids from carboxyl labeled acetate, while the conversion to cholesterol was not affected and there was only a slight decrease in acetate oxidation. After 5 to 10 days of exposure to cold, fatty acid synthesis was partly restored, CO2 production had risen above normal, and cholesterol synthesis was still not greatly affected. Glucose added to the medium in 400 mgm. concentration was found to increase liver fatty acid synthesis in the cold-exposed as well as the control animals, as did glucose administered by stomach tube before the experiment. The evidence indicated that fatty acid synthesis was a linear function of the liver carbohydrate content at levels about 4 or above, but that acetate oxidation by liver was depressed only at much lower levels of carbohydrate content. The effect of glucose on cholesterol synthesis was obscure, except a marked increase of cholesterogenesis was observed when a cold-exposed animal was flooded with carbohydrate. Author

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE