Accession Number:

AD0293164

Title:

THE EFFECT OF TRACHOMA VIRUS VACCINE ON THE COURSE OF EXPERIMENTAL TRACHOMA INFECTION IN BLIND HUMAN VOLUNTEERS

Descriptive Note:

Corporate Author:

NAVAL MEDICAL RESEARCH UNIT NO 2 MANILA (PHILIPPINES)

Personal Author(s):

Report Date:

1961-12-29

Pagination or Media Count:

1.0

Abstract:

The results of bacteriologic cultures of six volunteers provided important evidence that the large virus agents isolated from trachomatous eyes are the etiologic agent of trachoma and have shown that vaccine prepared from egg yolk sac grown virus exerts a favorable influence on the course of experimental trachoma infections. An antibody response to the vaccine was demonstrated and there was a modification of disease in the vounteers receiving vaccine. While the three volunteers who received placebo each developed cross infection of their uninoculated eye and had an acute reactivation of the bilateral disease after 1 to 2 months of antibiotic eye ointment therapy, the vaccinated volunteers remained free of infection in uninoculated eyes and showed no relapse after ointment therapy. Treatment with sulfamethoxypyridazine, a sulfa drug with prolonged action, proved to be an effective and relatively simple method of therapy for experimental trachoma. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE