PHARMACOLOGY AND TOXICOLOGY OF 1,1-DIMETHYL-HYDRAZINE (UDMH)
AIR FORCE AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH
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The acute LD50 of UDMH in mice, rats, dogs, and monkeys by intraperitoneal administration was found to be 125 mgkg, 104 mgkg, 60-100 mg kg, and 60-100 mgkg, respectively. All animals exhibited clonic-tonic convulsions as the predominant symptom, and death was via respiratory arrest. Dogs and monkeys routinely showed emesis within 15-60 minutes following dose of UDMH, regardless of route. In the anesthetized dog UDMH did not alter the effects of epinephrine, norepinephrine, acetylcholine, histamine, or reserpine on blood pressure. It did not significantly affect autonomic ganglia or postganglionic nerve endings, nor did it markedly alter the electrocardiogram or blood pressure in 1-2 hours. In the unanesthetized dog, however, blood pressure was significantly increased until convulsions and respiratory arrest occurred.