Accession Number:

AD0291853

Title:

STEROID-PROTEIN INTERACTIONS

Descriptive Note:

Corporate Author:

LOUISVILLE UNIV KY

Personal Author(s):

Report Date:

1962-12-15

Pagination or Media Count:

1.0

Abstract:

Studies on Sprague-Dawle rats have shown that the high-affinity corticosteroid-binding activity of serum increases after adrenalectomy or hypophysectromy. This increa e becomes apparent etween the first and sec nd day after adrenalectomy, goes up to approximately twice the normal binding activity and remains at this level for at least 3 weeks. Injection of large doses of corticosterone into the adrenalectomized rat decreases the corticosteroid-binding activity to the same low level as observed in n rmal rat after injection of the same dose of corticosterone. A species-specificity was demonstrated the binding protein in rat ser m was found to bind corticosterone more firmly than cortisol, whereas the opposite relationship was observe for human transcortin. Electrophoretic studies showed the corticosteroid-binding protein in rat serum to be an alpha globulin. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE