Accession Number:

AD0291638

Title:

EFFECT OF CORTISONE ON THE COURSE OF THE INFECTIOUS PROCESS IN WHITE MICE INFECTED WITH PATHOGENIC MICROORGANISMS

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Report Date:

1962-09-01

Pagination or Media Count:

18.0

Abstract:

Under experimental conditions cortisone considerably increased the sensitivity of white mice to pseudotuberculosis, listerellosis, pasteurellosis, erysipeloid, and salmonellosis therefore, cortisone-treated white mice can be employed as a very sensitive biotest in carrying out corresponding analyses. Cortisone markedly increased the sensitivity of white mice to the vaccine culture of plague and tularemia microorganisms and thus, can be utilized in individual experimental investigations. In experiments with highly virulent tularemia and plague cultures, to which white mice are highly sensitive even without cortisone, no further increase has been observed in the sensitivity of animals to infection tularemia, or their sensitivity increased only slightly plague. Upon examination of wild rodents in the natural plague nidi, no advantages could be elicited from the use of cortisone-treated white mice for biological tests.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE