Accession Number:

AD0288876

Title:

DETERMINATION OF 1,1-DIMETHYLHYDRAZINE (UDMH) IN URINE

Descriptive Note:

Technical rept.

Corporate Author:

AIR FORCE AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH

Personal Author(s):

• Diamond, Philip
• Thomas, Anthony A.

Report Date:

1962-10-01

Pagination or Media Count:

15.0

Abstract:

The colorimetric determination of 1,1-dimethylhydrazine UDMH in urine using trisodium pentacyanoamino ferroate TPF has heretofore been hampered by interfering substances in urine which resulted in poor recovery and some false negative results. A procedure was developed which overcame this difficulty and was primarily designed to determine rapidly in an emergency situation the urinary concentration of UDMH in exposed personnel. The procedure involves a hydrogen peroxide treatment of the urine followed by a colorimetric complexing of UDMH with TPF. In vivo results are presented on dogs that received intraperitoneal doses of UDMH with urinary concentrations of UDMH being determined in spontaneously voided and 24-hour pooled specimens. The results give some indication of the relationship of dose to excretion levels. In vitro recovery in 100 human urine specimens is presented.

Descriptors:

• *DIMETHYLHYDRAZINES
• *URINE
• IN VITRO ANALYSIS
• FERRITES
• PEROXIDES
• HYDROGEN COMPOUNDS
• COLORIMETRIC ANALYSIS
• EXPOSURE(PHYSIOLOGY)
• DOSE RATE

Subject Categories:

• Biochemistry
• Liquid Rocket Propellants

Distribution Statement:

APPROVED FOR PUBLIC RELEASE