Accession Number:

AD0287085

Title:

FURTHER STUDIES ON THE DISTRIBUTION AND METABOLISM OF 2-MERCAPTOETHYLGUANIDINE AND BIS (2-GUANIDOETHYL) DISULFIDE IN MICE

Descriptive Note:

Corporate Author:

ALBERT EINSTEIN MEDICAL CENTER PHILADELPHIA PA

Report Date:

1962-06-01

Pagination or Media Count:

1.0

Abstract:

GED bis2-guanidoethyldisulfide. The distribution of S35 in the various tissues and the metabolism of 2-mercaptoethylguanidineS-35 MEG-S35 and bis2-guanidoethyldisulfideS-35 GED-S35 as determined by chromatography of tissue homogenates were studied in 8- to 10week-old C57BL6J male mice. Protein-bound S35, GED, taurocyamine, guanidoethylsulfinic acid, MEG, and sulfate were identified in the tissues. Several unknown compounds were also observed. Concentrations of protein-bound S35 and GED decreased at 120 min after GED administration and correlated best with protection of the mice. All products increased in the tissues at the higher dose of MEG, but the protein-bound S35 did not increase as much as other products. Some differences in the concentrations of products were noted on compaison of MEG-trea ed with GED- treated animals. The relationship of these results to mechanism of action of MEG and GED is discssed. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE