Accession Number:

AD0287077

Title:

PYRIDOXAL PHOSPHATE HYDRAZONE AS A MEASURE OF 1,1-DIMETHYLHYDRAZINE CONGENTRATION IN TISSUES

Descriptive Note:

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Report Date:

1962-02-01

Pagination or Media Count:

1.0

Abstract:

A method is described for determining concentrations of 1,1-dimethylhydrazine UDMH in tissues. It is based on the spectral absorption of pyridoxal phosphate-UDMH hydrazone. By use of the described method, brain UDMH levels were determined in two groups of rats. Both groups received 120 mg.kg. UDMH one received additionally 100 mg.kg. pyridoxine hydrochloride. There were no apparent differences in the two groups either in the level of accumulating the hydrazide or in the rate of clearing it. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE