Accession Number:

AD0287074

Title:

EFFECT OF RESERPINE ON BODY TEMPERATURE REGULATION OF THE RAT

Descriptive Note:

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Report Date:

1962-02-01

Pagination or Media Count:

1.0

Abstract:

Daily intraperitoneal injections of reserpine were found to lower the colonic temperature of rats maintained at room temperature 25 C. only if the dose was 1.0 mg.kg. or greater. Much smaller doses 0.125 mg.kg. of the drug significantly increased the rate at which these animals cooled when exposed to reduced environmental temperatures 5 and 14 C.. Metabolic studies indicated that decreased heat production rather than increased heat loss was the mech-ANISM WHEREBY RESERPINE EXERTED ITS EFFECT ON COOLING RATE. Physiologic doses of thyroxine 50 microgramskg. were found to improve the metabolic response of reserpine-treated rats to cold and to return their cooling rates toward control values. TSH thyroid stimulating hormone administration to reserpine-treated rats did not improve their response to cold. These observations suggested that reserpine may interfere with the normal response of the thyroid gland to stimulation by TSH, but not to peripheral utilization of thyroid hormone. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE