Immunological Studies with Bacillus Anthracis. Bacillus Anthracis Aerosol Challenge of Guinea Pigs Vaccinated with Protective Antigen.
ARMY BIOLOGICAL LABS FREDERICK MD
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This study indicated that three separate injections of Bacillus anthracis protective antigen provided a higher level of immunity than one injection when guinea pigs were challenged by the respiratory route with two different strains V1B and NH6 of Bacillus anthracis. Based on LD5O values obtained with control animals, protective antigen provided a higher level of resistance against intracutaneous route of challenge than the respiratory. Immunized animals challenged intracutaneously with strain NH6 displayed a much lower level of resistance against this route than that observed for strain VlB. Averaged LD5O values obtained with control guinea pigs indicated that strain VlB was more virulent via the respiratory route than strain NH6.