Accession Number:

AD0276708

Title:

HAPTENIC PROPERTIES OF PARALYTIC SHELLFISH POISON

Descriptive Note:

Quarterly progress rept. no. 7, 1 Jan-30 Mar 1962

Corporate Author:

ROBERT A TAFT SANITARY ENGINEERING CENTER CINCINNATI OH

Personal Author(s):

• Campbell, J. E.

Report Date:

1962-04-01

Pagination or Media Count:

24.0

Abstract:

Injection of paralytic shellfish poison PSP conjugated to formalin- treated bovine serum albumin PSP-HCHO-BSA into rabbits resulted in the production of sera capable of precipitating with their homologous antigen as well as with formalin treated heterologous protein. Anti-PSPHCHO-BSA sera of high titer and strong reactivity were capable of protecting white mice from the lethal action of PSP when injected I.P. with serum and later challenged by the same route. Passive immunity was not conferred to mice which received sera that showed little or no ability to precipitate PSP-HCHO-BSA. Evidence is presented to indicate that PSP does not exist in a stable protein conjugate in frozen Gonyaulaux catenella cells.

Descriptors:

• *MUSSEL POISONS
• PREPARATION
• TOXICITY
• PURIFICATION
• ANTIBODIES
• SEPARATION
• MICE
• IMMUNITY
• ANTIGENS
• RABBITS

Subject Categories:

• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE