Accession Number:

AD0276169

Title:

EFFECTS OF SUGARS ON THE SURVIVAL OF SERRATIA MARCESCENS AFTER FREEZE DRYING OR AEROSOLIZATION AT UNFAVORABLE HUMIDITY

Descriptive Note:

Technical manuscript no. 6

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1962-05-01

Pagination or Media Count:

16.0

Abstract:

Suspensions of Serratia marcescens were subjected to freeze drying or to aerosolization at unfavorable humidity levels. The survival of the cells during these treatments was markedly improved in the presence of common sugars, but no one sugar stabilized the cells against both stresses. The protective effects of the sugars were correlated with their penetrability into cells minimally penetrable MP sugars stabilized cells against aerosolization and freely penetrable FP sugars stabilized cells during freeze drying. These results were attributed to the modifications of intracellular water content induced by the presence of the sugars in the cell suspensions.

Subject Categories:

  • Microbiology
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE