Accession Number:

AD0276046

Title:

STUDIES ON RADIATION-INDUCED CHIMERAS, EARLY DEVELOPMENT OF GRAFT-TO-HOST TOLERANCE; PREVENTION OF SECONDARY DISEASE BY ISOANTISERUM AND PREIRRADIATION OF MARROW DONOR

Descriptive Note:

Corporate Author:

NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s):

Report Date:

1962-04-30

Pagination or Media Count:

1.0

Abstract:

The present experiments are concerned with the attempt to prevent or ameliorate the occurrence of secondary disease deaths in irradiated mice bearing foreign bone marrow grafts in addition, certain aspects of graft-to-host tolerance in early radiation chimeras have been investigated. It is concluded that specific graft-to-host tolerance may develop relatively early in radiation chimeras, that it is possible to prevent or eliminate secondary disease in homologous radiation chimeras by suitable preirradiation of the marrow donors, and by injection into the chimeras of specific isoantiserum directed against the marrow donor. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE