TISSUE TRANSPLANTATION: HOMOGRAFT ANTIGENS, IONIZING RADIATION AND OTHER FACTORS INFLUENCING HOMOGRAFT SURVIVAL
Progress rept. 1 Jun 1961-31 May 1962
HARVARD MEDICAL SCHOOL BOSTON MA
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The best survival achieved thus far for the canine renal homograft followed a program consisting of the initial administration of 6 mercaptopurine, with BW57-322 given as a daily dose, with periodic addition of Actinomycin C. With this program, more than half of the dogs survived more than 30 days, with the renal homograft as the only renal tissue in the recipient. A similar program followed in man for the first time resulted in the longest survival obtained thus far with chemical treatment only. The characteristics of synthetic polypeptides as antigens were defined further. Amino acid content as well as sequence are important determinants of antigenicity. This is borne out also by examination of the inhibitory effects on antigen-antibody combination by amino acids and dipeptides.
- Medicine and Medical Research