Accession Number:

AD0272758

Title:

BASIC STUDIES IN PERCUTANEOUS ABSORPTION

Descriptive Note:

Semi-annual rept. Jul-Dec 61

Corporate Author:

LEVER BROS CO EDGEWATER NJ

Report Date:

1961-12-01

Pagination or Media Count:

83.0

Abstract:

Alterations in the skin of rats maintained on a fat-free EFA- deficient diet were studied by biological, chemical and physical techniques. Skin from EFA-deficient rats showed parakeratosis, acanthosis and hypertrophy of the sebaceous glands. The water diffusion rate and electrical conductivity of skin rose sharply after six weeks of feeding the EFA-deficient diet. Also, EFA- deficient skin was more permeable to organic acids, amino acids, glucose and urea than normal skin. The permeability of skin from rats on diets deficient in vitamins A, B6 and C was not altered. Skin permeability did not change in cases of magnesium deficiency or when low or high protein diets were fed to rats. Treatment with olive oil and with petroleum ether caused a small increase in the permeability of skin to both water and ions. Experiments indicate that n-butylamine penetrates normal rat skin readily. Author

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE