Accession Number:

AD0272379

Title:

INCREASED CORTICOSTEROID BINDING (TRANSCORTIN) ACTIVITY IN ADRENALECTOMIZED AND HYPOPHYSECTOMIZED RATS

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s):

• WESTPHAL, U.
• WILLIAMS, W.C.
• ASHLEY, B.D.

Report Date:

1962-01-15

Pagination or Media Count:

8.0

Abstract:

Equilibrium dialysis experiments with pooled sera of rats demonstrate that the binding activity of the specific corticosteroid-binding protein transcortin is higher in adrenalectomized and hypophysectomized animals than in normal controls. Rat serum at both 4 C and 37 C has a higher binding affinity for corticosterone than for cortisol, whereas in human serum at 4 C, cortisol appears to be bound more fir ly than corticosterone. The transcortin systems of man and rat, therefore, show distinct differences. Author

Descriptors:

• *BIOCHEMISTRY
• *CORTICOSTEROID AGENTS
• ADRENAL GLANDS
• EXCISION
• HORMONES
• LABORATORY ANIMALS
• PITUITARY GLAND
• PRODUCTION
• PROTEINS
• STEROIDS
• STRESS(PHYSIOLOGY)

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE