Variability of Different Intact Human-Skin Sites to the Penetration of VX
CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD
Pagination or Media Count:
Because it was suspected there might be a variability in the sensitivity to penetration of anatomically different skin area, doses of from 5 to 30 microgramkg of VX were applied in a single drop to 19 intact skin sites on humans. Variations in penetration rates were determined from cholinesterase depression and incidence of symptoms. The following conclusions were reached 1. Cholinesterase depression by sublethal doses of VX and incidence of symptoms are directly correlated. 2. There is a difference in sensitivity to penetration by VX of various body sites, the head and neck areas being the most sensitive. 3. The more rapid the penetration rate, the more rapid is the onset of toxic signs and symptoms. 4. Oximes appear to be effective in the treatment of VX intoxication.
- Chemical, Biological and Radiological Warfare