Accession Number:

AD0271068

Title:

STEROID-PROTEIN INTERACTIONS. VIII. STRUCTURE OF DELTA (4)-3-KETOSTEROIDS IN RELATION TO SPECTROPHOTOMETRIC INTERACTION WITH HUMAN SERUM ALBUMIN

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Personal Author(s):

Report Date:

1961-09-20

Pagination or Media Count:

15.0

Abstract:

Spectrophotometric observations show that introduction of methyl into delta 4-3-ketosteroids strengthens the interaction with human serum albumin HSA. Increase of the electron density at the rear side of the steroid molecule weakens this interaction. Simple alpha, beta-unsaturated ketones interact with HSA in a way similar to delta 4-3-ketosteroids. The spectrometric results on the influence of functional groups in delta 4-3-ketosteroids on interaction with HSA are summarized. Observation of bathochromic shifts in the ultraviolet absorption of 6 betamethyl-substituted delta 4-3-ketosteroids confirms the concept of Ringold and Bowers that the inductive effect of a 6 beta-axial substituent is greater than that of the corresponding 6 alpha substituent. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE