Accession Number:

AD0270762

Title:

HAPTENIC PROPERTIES OF PARALYTIC SHELLFISH POISON

Descriptive Note:

Quarterly progress rept. no. 5, 1 Jul-30 Sep 61,

Corporate Author:

ROBERT A TAFT SANITARY ENGINEERING CENTER CINCINNATI OH

Personal Author(s):

Report Date:

1961-10-01

Pagination or Media Count:

13.0

Abstract:

The serological data collected to date on the immunogenic properties of diazotized PSP-protein conjugates reveal that these materials are capable of eliciting antibody production in rabbits which may be demonstrated by precipitin reactions, inhibition tests, skin tests, and complement fixation tests. The results indicate that the common moiety, among antigens composed of PSP conjugated to different proteins, is the altered PSP resulting from diazotization. None of several serological techniques employed provided conclusive evidence that antibodies to native PSP had been produced. Antibodies to diazotized PSP were demonstrated by means of inhibition, complement fixation and skin tests. Studies on the reactivity of PSP with aromatic diazonium salt have been further investigated, and procedures are described for the synthesis of PSP-biphenyl-ovalbumin and biphenyl-ovalbumin. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE