Accession Number:

AD0270592

Title:

INFLUENCE OF LARGE DOSES OF PYRIDOXINE HYDROCHLORIDE ON THE CONVULSIGENIC ACTIVITY OF UDMH IN MONKEYS

Descriptive Note:

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s):

• REEVES,JOHNIE L.

Report Date:

1961-12-01

Pagination or Media Count:

1.0

Abstract:

Earlier experiments, based on the finding that 1,1-dimethylhydrazine UDMH inhibited certain vitamin B6-requiring enzymes, showed that pyridoxine hydrochloride was very effective in either prophylaxis or therapy of UDMH-induced convulsions in rats. The current experiments show that pyridoxine hydrochloride is also an efficient antidote in monkeys. Author

Descriptors:

• *ENZYMES
• *METHYL HYDRAZINES
• *VITAMIN B COMPLEX
• INHIBITION
• THERAPY

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE