Accession Number:

AD0269983

Title:

THE SYNTHESIS OF POTENTIAL ANTI-RADIATION AGENTS

Descriptive Note:

Corporate Author:

YALE UNIV NEW HAVEN CONN

Personal Author(s):

Report Date:

1962-01-15

Pagination or Media Count:

1.0

Abstract:

Work concerned with the preparation of compounds in which the radioprotective 2-mercaptoethylamino grouping is attached to purines and pyrimidines, potentially capable of carrying it into nu leic acids, was completed. Since replacement of the sulfur of cysteamine with selenium does not destroy anti-radiation activity, the selenium analogs of a group of 2-aminoethylthiouronium salts, as well as their presumable physiological rearrangement products 2-aminoselenazolines and 2-selenoethylguanidines were prepared. The bis Bunte salt of bis2-mercaptoethylamine the doublearmed analog of cysteamine was synthesized. Author

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE