Accession Number:

AD0269825

Title:

BIOCHEMISTRY OF TOXIC PROTEINS. FRACTIONATION OF INDIAN COBRA VENOM BY COLUMN CHROMATOGRAPHY

Descriptive Note:

Corporate Author:

IIT RESEARCH INST CHICAGO ILL

Personal Author(s):

Report Date:

1962-01-16

Pagination or Media Count:

1.0

Abstract:

Indian cobra venom was fractionated chromatographically with dextran gels and carboxymethylcellulose CMC. Five fractions, including two with toxicity, were obtained from dextran gel of optimal cross-linkage. Resolution and yield were affected by the ratio of sample to absorbent. Twelve fractions from CMC included two with toxicity that were heat labile and stable, respectively. Most fractions by both methods of chromatography were heterogeneous by zone electrophoresis. Three bioassay methods showed different degrees of enrichment of toxicity. Author

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE