Accession Number:

AD0269488

Title:

INCREASE IN ACCELERATION TOLERANCE OF THE RAT BY 2-DIMETHYLAMINOETHYL P-CHLOROPHENOXYACETATE (LUCIDRIL)

Descriptive Note:

Corporate Author:

NAVAL AIR DEVELOPMENT CENTER JOHNSVILLE PA AVIATION MEDICAL ACCELERATION LAB

Personal Author(s):

Report Date:

1961-11-27

Pagination or Media Count:

1.0

Abstract:

The dimethylaminoethyl ester of parachlorophenoxyacetic acid enhanced significantly the tolerance of rats to acceleration at 20 G. The median survival time of treated animals increased to 33.3 min, almost a threefold increment. The effectiveness persisted only for a period of 4 hrAFTER INJECTION. A latent period of 3 to 4 days treatment seemed necessary before the enhanced tolerance to acceleration became apparent. The activity of the drug was dose-dependent in that no significant changes in acceleration tolerance were found with a total injection of 50 mg significant increments in tolerance were obtained with 75 mg of the drug much larger increases in the tolerance to acceleration followed administration of 100 mg of Lucidril. The nature of the pharmacologic effect suggests that the drug action per se is mediated via the hypothalamic area of the brain, possibly in interplay with the biogenic amines. The low toxicity of the drug and the fact that it has already been used in humans in high doses with no deleterious and some presumptive beneficial effects leads to the proposal that the compound might be effective in increasing human tolerance to acceleration stress. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE