Accession Number:

AD0269298

Title:

ACCELERATION OF BONE REPAIR BY CHONDROITIN SULFATE TREATMENT OF IMPLANTS

Descriptive Note:

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Report Date:

1961-07-01

Pagination or Media Count:

1.0

Abstract:

A histologic and roentgenographic study was made of the repair of bony defects in the calvaria of albino rats. An accelerated rate of bone repair was observed in wounds into which chondroitin sulfate-treated demineralized bone was implanted, as evidenced by maximum repair of the defect in 6 weeks, while 9 weeks were required for maximum healing when untreated demineralized bone was used. In addition, acid-soluble collagen precipitated with chondroitin sulfate was more effective in the healing of the bony defect than was acid-soluble collagen precipitated with NaCl. In no case, however, were any of the materials used as effective as demineralized bone treated with chondroitin sulfate in causing the rapid repair of the bone. The possibility exists that chondroitin sulfate, or a complex of chondroitin sulfate with a protein, has, in these instances, acted as an induction factor for the formation of the new bone necessary to repair the bony defect. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE