Accession Number:

AD0266956

Title:

A STUDY OF THE BIOLOGICAL EFFECTS OF HIGH INTENSITY MICROSECOND PULSES OF X-IRRADIATION AS DETERMINED BY THE POST IRRADIATION TESTICULAR WEIGHT LOSS IN MICE

Descriptive Note:

Corporate Author:

LINFIELD RESEARCH INST MCMINNVILLE OREG

Report Date:

1961-11-30

Pagination or Media Count:

1.0

Abstract:

HE E POSURE OF IOLOGICAL MATERIALS TO HIGH DOSE RATE X-IRRADIATION WAS MADE PRACTICABLE BY THE RECENT DEVELOPMENT OF T-F emmission cathodes which permit the construction of high current x-ray tubes. This report presents the design and theoretical considerations of x-ray production and dose distribtuion for a tube with a cylindrical transmission target surrounding a reentrant cavity in which material may be pl ced for irradiation. X-ray dose measurements at the high dose rates achieved in the reentrant cavity required the design and calibration of a suitable dosimeter. A group of 53 CAF1 mice were exposed to microsecond pulses of x-radiation at dose rates of 17.1 or 23.1 x 10 to the 6th power rsec. Exposure was made in a single pulse or in 2, 3, or 5 pulses with 10 minute intervals between pulses. The dose-response curve for 28 day post irradiation testicular weight loss was determined. Comparison of these data with ata taken from the literature for testicular weight loss following x-irradiation at relatively low dose rates suggest that the level of testicular damage induced by the high intensity x-irradiation used is roughly comparable with that reported for low intensity experiments. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE