Accession Number:

AD0266880

Title:

BIOCHEMICAL AND PHYSIOLOGICAL FACTORS OF THE IMMUNE RESPONSE

Descriptive Note:

Corporate Author:

NATIONAL JEWISH HOSPITAL DENVER COLO

Report Date:

1961-12-01

Pagination or Media Count:

1.0

Abstract:

Rabbits were adapted for 30 days to high altitude before immunization by a single I. V. injection of bovine serum albumin BSA 10 mgkg body weight. The animals were bled periodically during the following 4 weeks. Subsequent samples could not be obtained because of an unseasonl snowstorm which closed the Mt. Evans facilities and made it necessary to terminate this phase of the experiment and transfer the animals to the Denver laboratories where further samples were taken. At the end of 10 weeks, at which time circulating antibody levels had reached very low levels, the animals were given a secondary I.V. challenge with BSA to determine if the sojourn at altitude had any lasting effects on the immune response. Control rabbits were kept in Denver altitude of 5,280 ft. and treated in the same way as the experimental group. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE