Accession Number:

AD0263255

Title:

REDUCTION OF RADIATION LETHALITY IN DOGS BY CHEMICAL MIXTURE

Descriptive Note:

Corporate Author:

ARMY MEDICAL RESEARCH LAB FORT KNOX KY

Report Date:

1961-08-15

Pagination or Media Count:

31.0

Abstract:

A total of 68 small dogs were individually exposed to supra-lethal doses of 600 r, 1.8 x LD100, of acute whole-body radiation from a cobalt 60 source. The administration of 4 to 5 mgkg of para-aminopropiophenone PAPP intravenously 30 minutes before, and 225 mg total dose of S, beta- aminoethylisothiuronium AET plus 32.5 mg total dose of serotonin intraperitoneally 10 to 15 min before irradiation provided 58 survival, whereas the administration of PAPP alone protected only 13. By supplementing this pre- irradiation chemical treatment with postirradiation supportive therapy consisting of antibiotics, vitamins, parenteral fluids, and whole-blood transfusions, the survival of the PAPP treated dogs was increased to 63, while the survival of the dogs receiving the chemical mixture was increased to 8 AD- 328 454Div. 221 U TISTWRD Naval Ordnance Test Station, China Lake, Calif. THE THERMAL DECOMPOSITION CHARACTERISTICS OF EXPLOSIVES .. RR ee pp tt .. MM

Subject Categories:

  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE