HAPTENIC PROPERTIES OF PARALYTIC SHELLFISH POISON
Quarterly progress rept. no. 1, 1 Jul-30 Sep 1960
ROBERT A TAFT SANITARY ENGINEERING CENTER CINCINNATI OH
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In addition to completing orientation studies with non-toxic simulants for paralytic shellfish poison and a known haptenic system based on Hapamine, preliminary evidence was obtained which suggests the formation of a stabile diazo-derivative of the poison. This compound was given an opportunity to combine with ovalbumin, and the complex was used as the first experimental antigen. Failure of this preparation to elicit antibodies in rabbits was probably due to the fact that its toxicity prevented injection of sufficient antigen to develop a detectable titer. Plans are outlined for further chemical and immunological studies designed to overcome this difficulty.
- Chemical, Biological and Radiological Warfare