Accession Number:

AD0263130

Title:

HAPTENIC PROPERTIES OF PARALYTIC SHELLFISH POISON

Descriptive Note:

Quarterly progress rept. no. 1, 1 Jul-30 Sep 1960

Corporate Author:

ROBERT A TAFT SANITARY ENGINEERING CENTER CINCINNATI OH

Personal Author(s):

Report Date:

1960-10-10

Pagination or Media Count:

16.0

Abstract:

In addition to completing orientation studies with non-toxic simulants for paralytic shellfish poison and a known haptenic system based on Hapamine, preliminary evidence was obtained which suggests the formation of a stabile diazo-derivative of the poison. This compound was given an opportunity to combine with ovalbumin, and the complex was used as the first experimental antigen. Failure of this preparation to elicit antibodies in rabbits was probably due to the fact that its toxicity prevented injection of sufficient antigen to develop a detectable titer. Plans are outlined for further chemical and immunological studies designed to overcome this difficulty.

Subject Categories:

  • Toxicology
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE