Accession Number:

AD0261756

Title:

MAINTENANCE OF CARBOHYDRATE STORES DURING STRESS OF COLD AND FATIGUE IN RATS PREFED DIETS CONTAINING ADDED GLYCINE

Descriptive Note:

Corporate Author:

OREGON UNIV PORTLAND MEDICAL SCHOOL

Personal Author(s):

Report Date:

1961-03-01

Pagination or Media Count:

1.0

Abstract:

Rats prefed for 36 or 48 hr on a synthetic diet containing 10 added glycine show a marked ability to maintain carbohydrate stores following stresses compared to animals fed the diet without glycine. The stresses employed include a 24 hr fast, a large dose of insulin, cold, and cold with fatigue. During a 3-hr recovery period following the stress of swimming in cold water, rats prefed the glycine diet synthesize large amounts of liver glycogen. It is proposed that this represents increased glyconeogenesis. Adrenalectomized rats do not show this effect. However, after giving hydrocortisone the effect is again clearly evident, indicating that the adrenal cortex is involved in t phenomenon. When the swimming stress is shortened, the glycine effect is bolished. The prefeedi g perio on the glycine diet can be reduced to 24 hr, or possibly less, without eliminating this effect. Liver transaminase activity is the same in animals on the two diets after stress and following recovery after stress. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE